FEM1B

Across TCGA cell cohorts, FEM1B mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. CNS shows the largest number of these associations.

The most reproducible FEM1B-associated genes across cancer lineages are OR10W1, OR4F5, and GSG1L2. Each is linked with FEM1B in more than 1 cancer types. Because this analysis shows association rather than direction, both FEM1B-to-partner and partner-to-FEM1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by FEM1B-low versus FEM1B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FEM1B→partner) and Y-score (partner→FEM1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10W1 →	+0.016	+3.977	<.001	.001	3	1
LARGE_INTESTINE	OR4F5 →	+0.018	+3.345	<.001	.007	3	1
BLOOD_Leukemia	GSG1L2 →	+0.043	+4.969	<.001	.003	3	1
BLOOD_Lymphoma	ZIC3 →	+0.522	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	TMEM82 →	+0.026	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	KRTAP4-1 →	+0.151	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR10W1 by FEM1B expression — LARGE_INTESTINE

Explore this box plot interactively →