FEM1AP4

Across TCGA pan-cancer cohorts, FEM1AP4 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated FEM1AP4 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher FEM1AP4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FEM1AP4 expression acts as an unfavorable survival marker, although some lineages such as LUSC and HNSC show a favorable association.

ACC, UVM, and LUAD are the cancer types where FEM1AP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.227	0.728	.012	48	view →
UVM	DFS	Tertile	III,IV	0.234	0.638	<.001	42	view →
LUAD	OS	Tertile	II,III,IV	0.589	0.785	.005	39	view →
LUSC	OS	Tertile	All	0.857	0.748	.009	36	view →
KICH	OS	Tertile	II,III,IV	0.653	0.944	.004	33	view →
LIHC	DFS	Tertile	All	0.155	0.316	.016	27	view →
COAD	OS	Tertile	IV	0.215	0.685	.006	18	view →
PCPG	OS	Quartile	All	0.707	0.981	.003	18	view →
LGG	DFS	Quartile	All	0.776	0.852	.010	17	view →
HNSC	OS	Tertile	IV	0.487	0.188	.027	12	view →
SKCM	OS	Median	II,III,IV	0.910	0.793	.032	7	view →
DLBC	DFS	Tertile	All	0.562	0.828	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

FEM1AP4–ACC (OS)

Open the ACC breakdown →