FEM1A

Across TCGA pan-cancer cohorts, FEM1A mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FEM1A data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher FEM1A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated FEM1A expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, LUAD, and GBM are the cancer types where FEM1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.909	0.603	.003	31	view →
LUAD	DFS	Quartile	III,IV	0.438	0.875	.040	3	view →
GBM	DFS	Quartile	All	0.271	0.612	.013	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

FEM1A–LSCC (OS)

Open the LSCC breakdown →