FEM1A

Across TCGA cell cohorts, FEM1A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,865 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FEM1A-associated GO terms across cancer lineages are Negative regulation of DNA-templated transcription, elongation, Epigenetic regulation of gene expression, and Regulation of chromatin organization. Each is linked with FEM1A in more than 16 cancer types. Because this analysis shows association rather than direction, both FEM1A-to-partner and partner-to-FEM1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of DNA-templated transcription, elongation grouped by FEM1A-low versus FEM1A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FEM1A→partner) and Y-score (partner→FEM1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of DNA-templated transcription, elongation →	+0.123	+0.566	.002	.006	3	17
BONE	Epigenetic regulation of gene expression →	+0.083	+0.849	<.001	<.001	3	16
BLOOD_Leukemia	Regulation of chromatin organization →	+0.067	+0.486	<.001	<.001	3	16
OVARY	Negative regulation of chromosome condensation →	+0.165	+0.524	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Negative regulation of protein localization to chromatin →	+0.169	+0.644	<.001	.003	3	15
BONE	U2-type prespliceosome assembly →	+0.111	+0.838	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,865 associations by consensus.

Negative regulation of DNA-templated transcription, elongation by FEM1A expression — BONE

Explore this box plot interactively →