FEM1A

Across TCGA cell cohorts, FEM1A mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FEM1A-associated genes across cancer lineages are C9orf92, CLRN2, and EPPIN. Each is linked with FEM1A in more than 1 cancer types. Because this analysis shows association rather than direction, both FEM1A-to-partner and partner-to-FEM1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf92 grouped by FEM1A-low versus FEM1A-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FEM1A→partner) and Y-score (partner→FEM1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C9orf92 →	+0.194	+5.369	<.001	.004	3	1
SOFT_TISSUE	CLRN2 →	+0.026	+5.369	<.001	.004	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	NKX2-6 →	+0.639	+5.201	<.001	.006	3	1
BLOOD_Leukemia	WFDC11 →	+0.041	+5.539	<.001	.003	3	1
BLOOD_Leukemia	OR52E4 →	+0.012	+5.201	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

C9orf92 by FEM1A expression — SOFT_TISSUE

Explore this box plot interactively →