FECH

Across TCGA pan-cancer cohorts, FECH mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FECH data layer compared with 20 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FECH mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FECH expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

UCEC, CCRCC, and PDAC are the cancer types where FECH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.477	0.936	.004	16	view →
CCRCC	OS	Quartile	All	0.963	0.769	.018	7	view →
PDAC	DFS	Tertile	IV	0.934	0.228	.024	6	view →
GBM	DFS	Quartile	All	0.857	0.676	.025	4	view →
HNSC	DFS	Median	III,IV	0.880	0.701	.018	3	view →
LUAD	OS	Quartile	II,III,IV	0.510	1.000	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FECH–UCEC (DFS)

Open the UCEC breakdown →