FECH

Across TCGA patient cohorts, FECH mutation is significantly associated with the RNA expression of many other genes, with 900 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FECH-associated genes across cancer lineages are CERT1, SRSF4, and EXOSC9. Each is linked with FECH in more than 1 cancer types. Because this analysis shows association rather than direction, both FECH-to-partner and partner-to-FECH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CERT1 grouped by FECH-low versus FECH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FECH→partner) and Y-score (partner→FECH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CERT1 →	+0.721	+1.880	<.001	.005	3	2
UCEC	SRSF4 →	+0.321	+2.471	.007	.001	3	2
UCEC	EXOSC9 →	+0.423	+1.869	.004	.005	3	2
UCEC	TUBGCP4 →	+0.473	+1.938	<.001	.009	3	2
UCEC	FANCI →	+0.634	+2.000	<.001	.009	3	2
UCEC	GID4 →	+0.402	+1.869	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 900 associations by consensus.

CERT1 by FECH expression — UCEC

Explore this box plot interactively →