FDX2

Across TCGA patient cohorts, FDX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,162 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible FDX2-associated GO terms across cancer lineages are [2Fe-2S] cluster assembly, [4Fe-4S] cluster assembly, and Regulation of termination of DNA-templated transcription. Each is linked with FDX2 in more than 31 cancer types. Because this analysis shows association rather than direction, both FDX2-to-partner and partner-to-FDX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, [2Fe-2S] cluster assembly grouped by FDX2-low versus FDX2-high in DLBC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FDX2→partner) and Y-score (partner→FDX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	[2Fe-2S] cluster assembly →	+0.071	+1.197	<.001	<.001	3	32
DLBC	[4Fe-4S] cluster assembly →	+0.105	+1.172	<.001	<.001	3	31
DLBC	Regulation of termination of DNA-templated transcription →	-0.098	-0.954	<.001	<.001	3	27
DLBC	Citrate metabolic process →	-0.066	-0.927	<.001	<.001	3	27
GBM	Regulation of electron transfer activity →	+0.046	+0.320	<.001	<.001	3	26
GBM	Regulation of cytochrome-c oxidase activity →	+0.043	+0.328	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,162 associations by consensus.

[2Fe-2S] cluster assembly by FDX2 expression — DLBC

Explore this box plot interactively →