FDX2

Across TCGA patient cohorts, FDX2 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FDX2-associated genes across cancer lineages are OR10T2, RNU6-164P, and MIR1267. Each is linked with FDX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FDX2-to-partner and partner-to-FDX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10T2 grouped by FDX2-low versus FDX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FDX2→partner) and Y-score (partner→FDX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR10T2 →	+0.055	+5.582	.009	.002	3	2
LUAD	RNU6-164P →	+0.754	+7.108	<.001	<.001	3	1
LUAD	MIR1267 →	+1.612	+5.410	<.001	.005	3	1
LUAD	LCEP4 →	+0.514	+5.343	.002	.006	3	1
LUAD	MTND4P18 →	+0.097	+5.888	<.001	.002	3	1
LUAD	CEACAMP8 →	+0.277	+5.217	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

OR10T2 by FDX2 expression — UCEC

Explore this box plot interactively →