FDX1

Across TCGA pan-cancer cohorts, FDX1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FDX1 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FDX1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FDX1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

PDAC, CCRCC, and COAD are the cancer types where FDX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	III,IV	0.278	0.959	<.001	26	view →
CCRCC	DFS	Tertile	III,IV	0.348	0.829	.004	18	view →
COAD	DFS	Median	III,IV	0.884	1.000	.022	12	view →
LSCC	OS	Median	II,III,IV	1.000	0.874	.010	7	view →
LUAD	OS	Median	All	0.597	0.834	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FDX1–PDAC (DFS)

Open the PDAC breakdown →