FDX1

Across TCGA patient cohorts, FDX1 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible FDX1-associated genes across cancer lineages are RN7SL863P, RNU6-352P, and MIR3169. Each is linked with FDX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FDX1-to-partner and partner-to-FDX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL863P grouped by FDX1-low versus FDX1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FDX1→partner) and Y-score (partner→FDX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SL863P →	+0.344	+7.954	<.001	.008	3	2
HNSC	RNU6-352P →	+0.708	+7.954	<.001	.008	3	2
HNSC	MIR3169 →	+0.528	+7.954	<.001	.008	3	2
HNSC	RNU6-666P →	+0.438	+7.954	<.001	.008	3	2
HNSC	RNA5SP407 →	+0.429	+7.954	<.001	.008	3	2
LUAD	RNA5SP157 →	+0.851	+7.930	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

RN7SL863P by FDX1 expression — HNSC

Explore this box plot interactively →