FDX1

Across TCGA cell cohorts, FDX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,850 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FDX1-associated GO terms across cancer lineages are P450-containing electron transport chain, Pyruvate decarboxylation to acetyl-CoA, and Negative regulation of focal adhesion disassembly. Each is linked with FDX1 in more than 16 cancer types. Because this analysis shows association rather than direction, both FDX1-to-partner and partner-to-FDX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, P450-containing electron transport chain grouped by FDX1-low versus FDX1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FDX1→partner) and Y-score (partner→FDX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	P450-containing electron transport chain →	+0.193	+1.201	<.001	<.001	3	17
LUNG_SCLC	Pyruvate decarboxylation to acetyl-CoA →	+0.136	+0.602	.005	.004	2	11
URINARY_TRACT	Negative regulation of focal adhesion disassembly →	+0.168	+0.920	<.001	.001	3	9
PANCREAS	DAMP biosynthetic process →	+0.127	+0.889	.003	.003	3	8
PANCREAS	Purine deoxyribonucleoside monophosphate biosynthetic process →	+0.127	+0.889	.003	.003	3	8
LIVER	mRNA methylguanosine-cap decapping →	+0.143	+0.973	.009	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,850 associations by consensus.

P450-containing electron transport chain by FDX1 expression — BONE

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