FCSK

Across TCGA patient cohorts, FCSK mutation is significantly associated with the RNA expression of many other genes, with 1,874 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCSK-associated genes across cancer lineages are ABHD5, NOCT, and SAR1B. Each is linked with FCSK in more than 2 cancer types. Because this analysis shows association rather than direction, both FCSK-to-partner and partner-to-FCSK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ABHD5 grouped by FCSK-low versus FCSK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCSK→partner) and Y-score (partner→FCSK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ABHD5 →	+0.468	+3.008	.005	<.001	3	3
UCEC	NOCT →	+0.590	+2.818	<.001	.001	3	2
UCEC	SAR1B →	+0.343	+2.459	.008	<.001	3	2
UCEC	JAKMIP1 →	+0.433	+3.000	.005	.001	3	2
UCEC	CD96 →	+0.617	+3.711	<.001	<.001	3	2
UCEC	DGKE →	+0.387	+1.736	.007	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,874 associations by consensus.

ABHD5 by FCSK expression — UCEC

Explore this box plot interactively →