FCSK

Across TCGA patient cohorts, FCSK mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCSK-associated genes across cancer lineages are GAPDH, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with FCSK in more than 2 cancer types. Because this analysis shows association rather than direction, both FCSK-to-partner and partner-to-FCSK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by FCSK-low versus FCSK-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCSK→partner) and Y-score (partner→FCSK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.505	+2.708	.014	.003	3	3
UCEC	Caspase-7-cleavedD198 →	+0.854	+3.584	<.001	.002	3	3
UCEC	EGFR_pY1068 →	-0.251	-2.584	.009	.010	3	2
UCEC	Lck →	+0.211	+2.087	.006	.005	3	2
UCEC	ATM →	-0.579	-3.571	<.001	.002	3	2
COAD	PCNA →	+0.299	+2.008	.002	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

GAPDH by FCSK expression — COAD

Explore this box plot interactively →