FCRLA

Across TCGA patient cohorts, FCRLA mutation is significantly associated with the RNA expression of many other genes, with 850 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCRLA-associated genes across cancer lineages are HMGN1P32, MIR30B, and LSS. Each is linked with FCRLA in more than 2 cancer types. Because this analysis shows association rather than direction, both FCRLA-to-partner and partner-to-FCRLA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGN1P32 grouped by FCRLA-low versus FCRLA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCRLA→partner) and Y-score (partner→FCRLA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMGN1P32 →	+0.122	+2.582	.007	.003	3	3
STAD	MIR30B →	+0.597	+3.741	<.001	.003	3	3
UCEC	LSS →	+0.577	+2.513	.001	.009	3	2
UCEC	PTH1R →	-0.805	-2.896	.007	.002	3	2
UCEC	TOP3A →	+0.559	+3.753	<.001	<.001	3	2
UCEC	ATP6V0A1 →	+0.480	+3.364	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 850 associations by consensus.

HMGN1P32 by FCRLA expression — UCEC

Explore this box plot interactively →