FCRL6

Across TCGA cell cohorts, FCRL6 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FCRL6-associated genes across cancer lineages are SIM1, CLEC10A, and NXPH2. Each is linked with FCRL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both FCRL6-to-partner and partner-to-FCRL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIM1 grouped by FCRL6-low versus FCRL6-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCRL6→partner) and Y-score (partner→FCRL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SIM1 →	+0.705	+3.836	<.001	.003	3	1
SKIN	CLEC10A →	+0.028	+3.688	<.001	.002	3	1
SKIN	NXPH2 →	+0.851	+3.611	.004	.006	3	1
SKIN	C11orf53 →	+0.363	+3.882	<.001	.001	3	1
SKIN	C1QC →	+0.024	+3.196	<.001	.007	3	1
SKIN	C1QB →	+0.071	+3.196	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

SIM1 by FCRL6 expression — SKIN

Explore this box plot interactively →