FCRL5

Across TCGA patient cohorts, FCRL5 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCRL5-associated genes across cancer lineages are eIF4E, Cyclin-B1, and 4E-BP1. Each is linked with FCRL5 in more than 4 cancer types. Because this analysis shows association rather than direction, both FCRL5-to-partner and partner-to-FCRL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by FCRL5-low versus FCRL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCRL5→partner) and Y-score (partner→FCRL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.158	+1.473	.014	.006	3	5
UCEC	Cyclin-B1 →	+0.536	+2.999	.001	<.001	3	5
UCEC	4E-BP1 →	+0.343	+2.277	<.001	<.001	3	4
LUSC	Rb_pS807_S811 →	+0.363	+2.807	.012	.002	3	3
LUAD	p62 Lck ligand →	+0.677	+2.338	.001	.019	3	3
COAD	Caspase-7-cleavedD198 →	+1.127	+3.330	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

eIF4E by FCRL5 expression — UCEC

Explore this box plot interactively →