FCRL5

Across TCGA cell cohorts, FCRL5 mutation is significantly associated with the RNA expression of many other genes, with 326 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FCRL5-associated genes across cancer lineages are HRH4, CXCL3, and CXCL1. Each is linked with FCRL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both FCRL5-to-partner and partner-to-FCRL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HRH4 grouped by FCRL5-low versus FCRL5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCRL5→partner) and Y-score (partner→FCRL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HRH4 →	+0.046	+2.263	.003	.007	3	2
LARGE_INTESTINE	CXCL3 →	+2.105	+2.502	<.001	.005	3	2
LARGE_INTESTINE	CXCL1 →	+2.130	+2.502	<.001	.005	3	2
LARGE_INTESTINE	FAM53A →	+0.521	+2.502	.002	.005	3	2
LARGE_INTESTINE	SMAD2 →	+0.762	+2.502	.004	.005	3	2
LARGE_INTESTINE	H4C1 →	+0.572	+2.502	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 326 associations by consensus.

HRH4 by FCRL5 expression — LARGE_INTESTINE

Explore this box plot interactively →