FCRL3

Across TCGA patient cohorts, FCRL3 mutation is significantly associated with the RNA expression of many other genes, with 6,021 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCRL3-associated genes across cancer lineages are RFC5, AUNIP, and SKA1. Each is linked with FCRL3 in more than 4 cancer types. Because this analysis shows association rather than direction, both FCRL3-to-partner and partner-to-FCRL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFC5 grouped by FCRL3-low versus FCRL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCRL3→partner) and Y-score (partner→FCRL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RFC5 →	+0.489	+1.627	<.001	<.001	3	5
UCEC	AUNIP →	+0.580	+2.939	<.001	<.001	3	5
UCEC	SKA1 →	+0.587	+2.010	<.001	<.001	3	4
LUAD	POC1A →	+0.551	+3.339	.003	.005	3	4
UCEC	PBK →	+0.899	+2.010	<.001	<.001	3	4
UCEC	DEPDC1 →	+0.543	+1.595	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,021 associations by consensus.

RFC5 by FCRL3 expression — UCEC

Explore this box plot interactively →