FCRL3

Across TCGA patient cohorts, FCRL3 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCRL3-associated genes across cancer lineages are Cyclin-B1, 4E-BP1, and FoxM1. Each is linked with FCRL3 in more than 3 cancer types. Because this analysis shows association rather than direction, both FCRL3-to-partner and partner-to-FCRL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by FCRL3-low versus FCRL3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCRL3→partner) and Y-score (partner→FCRL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-B1 →	+0.650	+3.467	.008	.002	3	4
LUAD	4E-BP1 →	+0.363	+3.182	.005	.009	2	4
SKCM	FoxM1 →	+0.161	+1.777	.013	.002	3	3
COAD	INPP4B →	-0.347	-3.169	.039	.018	3	3
UCEC	Shc_pY317 →	-0.144	-1.807	.001	.024	3	3
COAD	ATM →	-0.360	-2.313	.040	.035	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

Cyclin-B1 by FCRL3 expression — COAD

Explore this box plot interactively →