FCRL3

Across TCGA cell cohorts, FCRL3 mutation is significantly associated with the RNA expression of many other genes, with 672 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FCRL3-associated genes across cancer lineages are C20orf85, C16orf90, and TIMM50. Each is linked with FCRL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FCRL3-to-partner and partner-to-FCRL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf85 grouped by FCRL3-low versus FCRL3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCRL3→partner) and Y-score (partner→FCRL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C20orf85 →	+0.027	+3.969	<.001	.009	3	2
LUNG_SCLC	C16orf90 →	+0.048	+2.874	<.001	.007	3	2
LARGE_INTESTINE	TIMM50 →	+0.388	+2.158	.004	.004	3	2
LARGE_INTESTINE	METTL16 →	+0.472	+2.158	.003	.004	3	2
LARGE_INTESTINE	HOOK1 →	+0.860	+2.244	.001	.003	3	2
LARGE_INTESTINE	USP1 →	+0.590	+2.936	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 672 associations by consensus.

C20orf85 by FCRL3 expression — BLOOD_Leukemia

Explore this box plot interactively →