FCRL2

Across TCGA patient cohorts, FCRL2 mutation is significantly associated with the RNA expression of many other genes, with 3,732 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCRL2-associated genes across cancer lineages are CHEK1, CHAF1B, and RACGAP1. Each is linked with FCRL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FCRL2-to-partner and partner-to-FCRL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHEK1 grouped by FCRL2-low versus FCRL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCRL2→partner) and Y-score (partner→FCRL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHEK1 →	+0.695	+2.606	<.001	<.001	3	3
UCEC	CHAF1B →	+0.547	+2.679	<.001	<.001	3	3
UCEC	RACGAP1 →	+0.565	+2.021	.004	.005	3	3
UCEC	USP39 →	+0.324	+2.839	.002	.001	3	3
UCEC	PXMP2 →	+0.576	+2.016	.001	.001	3	3
UCEC	RAD51 →	+0.835	+2.654	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,732 associations by consensus.

CHEK1 by FCRL2 expression — UCEC

Explore this box plot interactively →