FCRL1

Across TCGA patient cohorts, FCRL1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCRL1-associated genes across cancer lineages are DJ-1, Acetyl-a-Tubulin-Lys40, and XRCC1. Each is linked with FCRL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FCRL1-to-partner and partner-to-FCRL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DJ-1 grouped by FCRL1-low versus FCRL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCRL1→partner) and Y-score (partner→FCRL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DJ-1 →	+0.201	+2.000	.007	.032	3	3
LUAD	Acetyl-a-Tubulin-Lys40 →	-0.557	-3.000	.037	.035	3	2
LUAD	XRCC1 →	+0.144	+1.762	.033	.049	3	2
UCEC	MEK1 →	+0.481	+3.459	.003	.005	3	2
UCEC	PCNA →	+0.228	+2.000	.019	.032	3	2
UCEC	4E-BP1 →	+0.386	+3.351	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

DJ-1 by FCRL1 expression — UCEC

Explore this box plot interactively →