FCN2

Across TCGA patient cohorts, FCN2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCN2-associated genes across cancer lineages are p38-MAPK_pT180_Y182, HER2, and Gab2. Each is linked with FCN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FCN2-to-partner and partner-to-FCN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by FCN2-low versus FCN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCN2→partner) and Y-score (partner→FCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.570	-2.308	.011	.036	3	2
SKCM	HER2 →	+0.404	+3.169	.001	.017	3	1
UCEC	Gab2 →	+0.548	+3.459	.002	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.200	-2.308	.018	.036	3	1
UCEC	NDRG1_pT346 →	-0.558	-3.169	.023	.019	3	1
UCEC	Notch1 →	+0.149	+2.321	.035	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

p38-MAPK_pT180_Y182 by FCN2 expression — UCEC

Explore this box plot interactively →