FCN1

Across TCGA pan-cancer cohorts, FCN1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FCN1 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher FCN1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FCN1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

GBM, CCRCC, and UCEC are the cancer types where FCN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.622	0.857	.014	4	view →
CCRCC	DFS	Tertile	II,III,IV	1.000	0.849	.018	4	view →
UCEC	OS	Median	II,III,IV	1.000	0.628	.013	4	view →
LUAD	OS	Quartile	II,III,IV	0.439	0.808	.006	2	view →
PDAC	OS	Median	III,IV	0.537	1.000	.008	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FCN1–GBM (DFS)

Open the GBM breakdown →