FCN1

Across TCGA cell cohorts, FCN1 mutation is significantly associated with the RNA expression of many other genes, with 379 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FCN1-associated genes across cancer lineages are CLPS, SPAG11B, and MRGPRX1. Each is linked with FCN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FCN1-to-partner and partner-to-FCN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLPS grouped by FCN1-low versus FCN1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCN1→partner) and Y-score (partner→FCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CLPS →	+0.083	+5.539	<.001	.003	3	1
BLOOD_Leukemia	SPAG11B →	+0.059	+5.201	.001	.006	3	1
BLOOD_Leukemia	MRGPRX1 →	+0.047	+5.201	<.001	.006	3	1
LARGE_INTESTINE	EIF3L →	+0.728	+3.409	<.001	<.001	3	1
LARGE_INTESTINE	FBXO7 →	+0.347	+3.169	.008	.009	3	1
LARGE_INTESTINE	HMGXB4 →	+0.583	+3.502	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 379 associations by consensus.

CLPS by FCN1 expression — BLOOD_Leukemia

Explore this box plot interactively →