FCHSD2

Across TCGA patient cohorts, FCHSD2 mutation is significantly associated with the RNA expression of many other genes, with 1,570 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCHSD2-associated genes across cancer lineages are FAM177A1, CENPU, and SLC25A4. Each is linked with FCHSD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FCHSD2-to-partner and partner-to-FCHSD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM177A1 grouped by FCHSD2-low versus FCHSD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCHSD2→partner) and Y-score (partner→FCHSD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAM177A1 →	+0.373	+1.903	<.001	<.001	3	2
UCEC	CENPU →	+0.566	+2.202	.001	<.001	3	2
UCEC	SLC25A4 →	+0.479	+2.024	<.001	.001	3	2
UCEC	GPATCH11 →	+0.383	+2.102	<.001	<.001	3	2
UCEC	C12orf43 →	+0.293	+2.496	<.001	<.001	3	2
UCEC	DONSON →	+0.488	+1.893	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,570 associations by consensus.

FAM177A1 by FCHSD2 expression — UCEC

Explore this box plot interactively →