FCHO2

Across TCGA patient cohorts, FCHO2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCHO2-associated genes across cancer lineages are Stathmin, eEF2, and EGFR_pY1068. Each is linked with FCHO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FCHO2-to-partner and partner-to-FCHO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Stathmin grouped by FCHO2-low versus FCHO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCHO2→partner) and Y-score (partner→FCHO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Stathmin →	+0.108	+1.765	.035	.014	3	2
UCEC	eEF2 →	+0.458	+2.700	<.001	.005	3	1
UCEC	EGFR_pY1068 →	-0.405	-2.662	<.001	<.001	3	1
UCEC	eIF4E →	+0.191	+2.169	.016	.003	3	1
UCEC	A-Raf_pS299 →	-0.173	-2.807	<.001	.003	3	1
UCEC	ERK2 →	+0.251	+1.765	<.001	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Stathmin by FCHO2 expression — UCEC

Explore this box plot interactively →