FCHO1

Across TCGA cell cohorts, FCHO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,907 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible FCHO1-associated GO terms across cancer lineages are Negative regulation of fibrinolysis, Purine ribonucleoside monophosphate catabolic process, and Symbiont-mediated disruption of host cell PML body. Each is linked with FCHO1 in more than 7 cancer types. Because this analysis shows association rather than direction, both FCHO1-to-partner and partner-to-FCHO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of fibrinolysis grouped by FCHO1-low versus FCHO1-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FCHO1→partner) and Y-score (partner→FCHO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Negative regulation of fibrinolysis →	-0.189	-0.651	<.001	.002	3	8
LUNG_SCLC	Purine ribonucleoside monophosphate catabolic process →	+0.157	+1.213	.003	.003	3	8
BLOOD_Lymphoma	Symbiont-mediated disruption of host cell PML body →	+0.088	+0.903	.001	<.001	3	7
BONE	Substrate adhesion-dependent cell spreading →	-0.210	-1.545	<.001	<.001	3	7
SOFT_TISSUE	IMP biosynthetic process →	+0.126	+2.703	<.001	<.001	3	7
BONE	Positive regulation of matrix metallopeptidase secretion →	+0.204	+1.074	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,907 associations by consensus.

Negative regulation of fibrinolysis by FCHO1 expression — CNS

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