FCGRT

Across TCGA patient cohorts, FCGRT mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCGRT-associated genes across cancer lineages are ETS-1, Ku80, and PCNA. Each is linked with FCGRT in more than 1 cancer types. Because this analysis shows association rather than direction, both FCGRT-to-partner and partner-to-FCGRT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ETS-1 grouped by FCGRT-low versus FCGRT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCGRT→partner) and Y-score (partner→FCGRT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ETS-1 →	+0.321	+3.459	.014	.005	3	2
UCEC	Ku80 →	+0.383	+4.100	<.001	<.001	3	2
UCEC	PCNA →	+0.182	+2.321	.041	.006	3	2
UCEC	ATM →	-0.603	-3.000	.001	.001	3	2
UCEC	4E-BP1 →	+0.229	+2.199	.040	.033	3	2
UCEC	eEF2 →	+0.445	+2.321	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ETS-1 by FCGRT expression — UCEC

Explore this box plot interactively →