FCGRT

Across TCGA cell cohorts, FCGRT mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FCGRT-associated genes across cancer lineages are DEFA4, PROP1, and OR6Q1. Each is linked with FCGRT in more than 1 cancer types. Because this analysis shows association rather than direction, both FCGRT-to-partner and partner-to-FCGRT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by FCGRT-low versus FCGRT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCGRT→partner) and Y-score (partner→FCGRT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LARGE_INTESTINE	PROP1 →	+0.020	+3.376	<.001	.002	3	1
LARGE_INTESTINE	OR6Q1 →	+0.012	+3.700	<.001	.009	3	1
BLOOD_Leukemia	PRMT8 →	+0.286	+2.824	<.001	.007	3	1
BLOOD_Leukemia	IMPG1 →	+0.066	+3.705	.001	.003	3	1
BLOOD_Leukemia	OR11H1 →	+0.051	+3.464	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

DEFA4 by FCGRT expression — LARGE_INTESTINE

Explore this box plot interactively →