Across TCGA pan-cancer cohorts, FCGR3A mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FCGR3A data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FCGR3A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FCGR3A expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LSCC, and GBM are the cancer types where FCGR3A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.930	0.696	.038	30	view →
LSCC	OS	Tertile	III,IV	0.943	0.477	.013	3	view →
GBM	OS	Median	All	0.287	0.482	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: FCGR3A tumor-vs-normal RNA expression · all FCGR3A data types