Across TCGA patient cohorts, FCGR3A mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCGR3A-associated genes across cancer lineages are 4E-BP1, EGFR_pY1068, and Acetyl-a-Tubulin-Lys40. Each is linked with FCGR3A in more than 1 cancer types. Because this analysis shows association rather than direction, both FCGR3A-to-partner and partner-to-FCGR3A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCGR3A→partner) and Y-score (partner→FCGR3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.348	+2.837	.005	.035	3	2
UCEC	EGFR_pY1068 →	-0.283	-2.584	.015	.011	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.558	+3.179	.018	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.220	-3.169	.005	.019	3	1
UCEC	JNK2 →	+0.334	+3.009	<.001	.019	3	1
UCEC	MEK1 →	+0.443	+3.321	.009	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

FCGR3A survival (RNA) · tumor vs normal (RNA) · all FCGR3A data types