FCGR2B

Across TCGA pan-cancer cohorts, FCGR2B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FCGR2B data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FCGR2B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated FCGR2B expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, COAD, and GBM are the cancer types where FCGR2B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.871	0.564	.001	52	view →
COAD	DFS	Tertile	II,III,IV	0.850	1.000	.035	12	view →
GBM	OS	Tertile	All	0.402	0.706	.004	12	view →
LUAD	DFS	Tertile	II,III,IV	0.840	0.312	.020	11	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	10	view →
CCRCC	DFS	Quartile	III,IV	0.078	0.904	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FCGR2B–HNSC (OS)

Open the HNSC breakdown →