FCER1A

Across TCGA patient cohorts, FCER1A mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCER1A-associated genes across cancer lineages are C-Raf, CDK1, and Fibronectin. Each is linked with FCER1A in more than 1 cancer types. Because this analysis shows association rather than direction, both FCER1A-to-partner and partner-to-FCER1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by FCER1A-low versus FCER1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCER1A→partner) and Y-score (partner→FCER1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.156	+2.000	.015	.032	3	2
SKCM	CDK1 →	+0.160	+1.584	.010	.032	3	2
UCEC	Fibronectin →	-0.341	-2.575	.022	.010	3	1
UCEC	Myosin-IIa_pS1943 →	+0.203	+2.321	.029	.034	3	1
UCEC	Rab25 →	-0.514	-2.321	<.001	.034	2	2
UCEC	Tuberin →	+0.292	+2.179	.016	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

C-Raf by FCER1A expression — UCEC

Explore this box plot interactively →