FCAMR

Across TCGA patient cohorts, FCAMR mutation is significantly associated with the RNA expression of many other genes, with 2,138 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCAMR-associated genes across cancer lineages are PFN1, SLC25A4, and CENPM. Each is linked with FCAMR in more than 1 cancer types. Because this analysis shows association rather than direction, both FCAMR-to-partner and partner-to-FCAMR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PFN1 grouped by FCAMR-low versus FCAMR-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCAMR→partner) and Y-score (partner→FCAMR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PFN1 →	+0.570	+3.210	.001	.009	3	2
UCEC	SLC25A4 →	+0.515	+2.272	<.001	.001	3	2
UCEC	CENPM →	+0.549	+1.938	.001	.001	3	2
UCEC	MCAT →	+0.380	+2.457	.001	.001	3	2
UCEC	MCM5 →	+0.501	+1.949	.002	.001	3	2
UCEC	TRMU →	+0.473	+2.768	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,138 associations by consensus.

PFN1 by FCAMR expression — COAD

Explore this box plot interactively →