FCAMR

Across TCGA patient cohorts, FCAMR mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCAMR-associated genes across cancer lineages are eEF2, EGFR_pY1068, and MEK1. Each is linked with FCAMR in more than 1 cancer types. Because this analysis shows association rather than direction, both FCAMR-to-partner and partner-to-FCAMR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by FCAMR-low versus FCAMR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCAMR→partner) and Y-score (partner→FCAMR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.370	+3.459	.004	.005	3	2
UCEC	EGFR_pY1068 →	-0.191	-2.584	.034	.010	3	2
UCEC	MEK1 →	+0.415	+2.321	.001	.001	3	2
UCEC	PDCD4 →	-0.547	-1.925	.001	.005	3	2
COAD	Shc_pY317 →	-0.214	-2.991	.014	.036	3	2
UCEC	Caspase-7-cleavedD198 →	+0.594	+1.925	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

eEF2 by FCAMR expression — UCEC

Explore this box plot interactively →