FBXW9

Across TCGA pan-cancer cohorts, FBXW9 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FBXW9 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FBXW9 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FBXW9 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where FBXW9 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.992	0.891	.006	16	view →
CCRCC	DFS	Quartile	II,III,IV	1.000	0.064	.024	14	view →
LSCC	DFS	Tertile	II,III,IV	0.897	1.000	.014	12	view →
PDAC	OS	Median	III,IV	0.329	0.865	.003	10	view →
LUAD	DFS	Median	All	0.745	0.406	.007	7	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FBXW9–HNSC (DFS)

Open the HNSC breakdown →