FBXW9

Across TCGA patient cohorts, FBXW9 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXW9-associated genes across cancer lineages are EGFR_pY1068, JNK_pT183_Y185, and Ku80. Each is linked with FBXW9 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXW9-to-partner and partner-to-FBXW9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by FBXW9-low versus FBXW9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW9→partner) and Y-score (partner→FBXW9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.327	-3.000	.024	.037	3	1
UCEC	JNK_pT183_Y185 →	-0.274	-2.986	.004	.037	3	1
UCEC	Ku80 →	+0.336	+3.013	.013	.019	3	1
UCEC	p27_pT157 →	-0.077	-2.960	.021	.036	3	1
UCEC	p62 Lck ligand →	+0.421	+2.817	.025	.036	3	1
UCEC	Rictor_pT1135 →	-0.157	-3.000	.008	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

EGFR_pY1068 by FBXW9 expression — UCEC

Explore this box plot interactively →