FBXW7

Across TCGA patient cohorts, FBXW7 mutation is significantly associated with the total protein of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXW7-associated genes across cancer lineages are Cyclin-E1, Cyclin-B1, and eIF4E. Each is linked with FBXW7 in more than 8 cancer types. Because this analysis shows association rather than direction, both FBXW7-to-partner and partner-to-FBXW7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E1 grouped by FBXW7-low versus FBXW7-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW7→partner) and Y-score (partner→FBXW7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	Cyclin-E1 →	+0.978	+3.700	<.001	<.001	2	9
READ	Cyclin-B1 →	+0.720	+3.906	.001	<.001	2	6
READ	eIF4E →	+0.241	+2.115	.003	.013	3	4
READ	FASN →	+0.523	+2.169	.003	.041	3	4
READ	PCNA →	+0.251	+2.807	.011	.002	3	4
CESC	Claudin-7 →	+0.528	+1.678	.014	.017	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

Cyclin-E1 by FBXW7 expression — READ

Explore this box plot interactively →