FBXW7

Across TCGA cell cohorts, FBXW7 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,865 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FBXW7-associated GO terms across cancer lineages are Negative regulation of SREBP signaling pathway, Regulation of SREBP signaling pathway, and Negative regulation of osteoclast development. Each is linked with FBXW7 in more than 18 cancer types. Because this analysis shows association rather than direction, both FBXW7-to-partner and partner-to-FBXW7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of SREBP signaling pathway grouped by FBXW7-low versus FBXW7-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW7→partner) and Y-score (partner→FBXW7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of SREBP signaling pathway →	+0.207	+1.627	<.001	<.001	3	19
LUNG_SCLC	Regulation of SREBP signaling pathway →	+0.108	+1.031	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Negative regulation of osteoclast development →	+1.254	+1.085	<.001	.008	3	16
KIDNEY	Positive regulation of mRNA metabolic process →	+0.059	+0.868	<.001	.009	3	15
LUNG_NSCLC_LUSC	Positive regulation of mRNA catabolic process →	+0.081	+1.018	.001	.002	3	15
BLOOD_Leukemia	Protein modification by small protein removal →	+0.051	+0.868	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,865 associations by consensus.

Negative regulation of SREBP signaling pathway by FBXW7 expression — LUNG_NSCLC_LUSC

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