FBXW5

Across TCGA pan-cancer cohorts, FBXW5 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FBXW5 data layer compared with 30 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FBXW5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FBXW5 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, LSCC, and HNSC are the cancer types where FBXW5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.361	0.187	.014	18	view →
LSCC	DFS	Median	III,IV	0.423	1.000	.003	16	view →
HNSC	OS	Median	All	0.826	0.622	.017	11	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

FBXW5–PDAC (DFS)

Open the PDAC breakdown →