FBXW2

Across TCGA pan-cancer cohorts, FBXW2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FBXW2 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FBXW2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FBXW2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

PDAC, CCRCC, and LUAD are the cancer types where FBXW2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	III,IV	0.369	0.977	.005	16	view →
CCRCC	OS	Median	All	0.909	0.754	.011	9	view →
LUAD	DFS	Median	All	0.950	0.885	.002	4	view →
GBM	DFS	Tertile	All	0.323	0.480	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

FBXW2–PDAC (OS)

Open the PDAC breakdown →