FBXW2

Across TCGA patient cohorts, FBXW2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXW2-associated genes across cancer lineages are ERK2, FASN, and JNK2. Each is linked with FBXW2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXW2-to-partner and partner-to-FBXW2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by FBXW2-low versus FBXW2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW2→partner) and Y-score (partner→FBXW2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.238	+3.169	.010	.019	3	1
UCEC	FASN →	-0.445	-3.000	.019	.036	3	1
UCEC	JNK2 →	+0.208	+2.834	.030	.034	3	1
UCEC	MSH6 →	-0.579	-3.584	<.001	.002	3	1
UCEC	p90 RSK →	+0.229	+2.472	.013	.011	3	1
UCEC	Annexin-1 →	+0.760	+3.019	.002	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ERK2 by FBXW2 expression — UCEC

Explore this box plot interactively →