FBXW2

Across TCGA cell cohorts, FBXW2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FBXW2-associated genes across cancer lineages are OR1N2, CNTN6, and FATE1. Each is linked with FBXW2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXW2-to-partner and partner-to-FBXW2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1N2 grouped by FBXW2-low versus FBXW2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW2→partner) and Y-score (partner→FBXW2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR1N2 →	+0.025	+5.029	<.001	.006	3	1
BLOOD_Leukemia	CNTN6 →	+0.216	+3.855	<.001	.007	3	1
BLOOD_Leukemia	FATE1 →	+0.106	+3.551	<.001	.009	3	1
BLOOD_Leukemia	KCNJ3 →	+0.627	+3.722	<.001	.009	3	1
BLOOD_Leukemia	WFDC12 →	+0.198	+3.874	<.001	.005	3	1
BLOOD_Leukemia	DEFB4A →	+0.096	+4.269	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

OR1N2 by FBXW2 expression — LUNG_SCLC

Explore this box plot interactively →