FBXW10

Across TCGA pan-cancer cohorts, FBXW10 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FBXW10 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FBXW10 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated FBXW10 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

UCEC, READ, and LIHC are the cancer types where FBXW10 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.933	0.434	.017	18	view →
READ	OS	Median	II,III,IV	0.166	0.829	<.001	17	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	12	view →
COAD	OS	Median	IV	0.045	0.659	<.001	12	view →
PRAD	DFS	Median	All	0.534	0.935	.033	2	view →
BLCA	DFS	Median	III,IV	0.771	0.267	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FBXW10–UCEC (DFS)

Open the UCEC breakdown →