FBXO7

Across TCGA patient cohorts, FBXO7 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO7-associated genes across cancer lineages are Notch1, Akt_pT308, and ATM. Each is linked with FBXO7 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO7-to-partner and partner-to-FBXO7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by FBXO7-low versus FBXO7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO7→partner) and Y-score (partner→FBXO7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.107	+1.362	.032	.037	3	2
UCEC	Akt_pT308 →	+0.508	+1.807	.022	.024	3	2
UCEC	ATM →	-0.562	-1.662	<.001	.011	3	2
UCEC	14-3-3_beta →	-0.115	-3.780	.001	<.001	3	1
UCEC	ERK2 →	+0.199	+2.000	.003	.009	3	1
UCEC	Heregulin →	-0.123	-1.678	.004	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Notch1 by FBXO7 expression — UCEC

Explore this box plot interactively →