FBXO6

Across TCGA pan-cancer cohorts, FBXO6 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated FBXO6 data layer compared with 28 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher FBXO6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FBXO6 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

COAD, LUAD, and UCEC are the cancer types where FBXO6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	All	0.885	1.000	.019	48	view →
LUAD	DFS	Median	All	0.974	0.856	.002	20	view →
UCEC	OS	Median	III,IV	1.000	0.433	.007	14	view →
CCRCC	OS	Median	All	0.656	1.000	.006	10	view →
HNSC	OS	Quartile	IV	0.956	0.654	.021	7	view →
LSCC	DFS	Tertile	All	0.982	0.891	.021	2	view →
GBM	OS	Quartile	All	0.264	0.569	.035	2	view →
PDAC	DFS	Tertile	II,III,IV	0.750	0.874	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

FBXO6–COAD (DFS)

Open the COAD breakdown →