FBXO45

Across TCGA pan-cancer cohorts, FBXO45 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FBXO45 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher FBXO45 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FBXO45 expression acts as an unfavorable survival marker, although some lineages such as OV and PDAC show a favorable association.

OV, CCRCC, and LUAD are the cancer types where FBXO45 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Tertile	All	0.978	0.683	.033	16	view →
CCRCC	DFS	Median	II,III,IV	0.451	1.000	.016	14	view →
LUAD	OS	Median	II,III,IV	0.862	1.000	.004	13	view →
PDAC	OS	Median	II,III,IV	0.590	0.389	.016	9	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.880	.010	4	view →
UCEC	OS	Tertile	All	0.910	1.000	.036	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FBXO45–OV (DFS)

Open the OV breakdown →