FBXO45

Across TCGA patient cohorts, FBXO45 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO45-associated genes across cancer lineages are STAT3_pY705, Caspase-7-cleavedD198, and TFRC. Each is linked with FBXO45 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO45-to-partner and partner-to-FBXO45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by FBXO45-low versus FBXO45-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO45→partner) and Y-score (partner→FBXO45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.557	-3.169	<.001	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+0.855	+3.019	.008	.019	3	1
UCEC	TFRC →	+0.646	+3.169	.026	.020	2	1
UCEC	EGFR_pY1068 →	-0.301	-3.169	.028	.020	1	1
UCEC	JNK_pT183_Y185 →	-0.223	-3.156	.016	.020	1	1
UCEC	p62 Lck ligand →	+0.397	+3.169	.026	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

STAT3_pY705 by FBXO45 expression — UCEC

Explore this box plot interactively →